Beauty/ Recent

SkinMedica TNS Advanced Serum Review

My obsession with skincare began in my mid-20s when I was having serious problems with acne. I tried countless lines for years and nothing worked. Eventually, I found a brand that DID work and I’ve enjoyed clear skin ever since. And now that I don’t have to fight acne, I feel like skincare is more fun! I LOVE trying new products and at age 37, I’m focused on hydration, preventing signs of aging and treating the fine lines and wrinkles I already have.

With those goals, I got a Diamond Glow facial a few months ago at a local plastic surgeon’s office. It was one of the best facials I had ever had, and I appreciated that the product recommendations they suggested could be added to my current skincare routine. So, I walked away from my appointment like a sucker with hundreds of dollars of products to take home, as one does. 😉 But, thankfully, the products I got truly blew me away, I was shocked by how much of a difference I noticed with my skin after using them just a few times. One of those products is the SkinMedica TNS Advanced Serum, which is what I’m going to review for you today. (The other was the iS Clinical Peel Pads, which I reviewed here.)

First, a little about the brand: SkinMedica is a medical grade skincare brand that makes all kinds of skincare products. It was co-founded by a renowned dermatologist, Dr. Richard Fitzpatrick, so everything was created with a doctor’s knowledge behind it, and it’s all incredibly high performing.

While I haven’t tried many other SkinMedica products, my wishlist is quickly growing based on my love for the TNS Advanced Serum. (My assistant uses and loves the skin rejuvenating moisturizer, and her gives it high praise too).

SkinMedica TNS Advanced Serum Review

Today I’m sharing the details of the SkinMedica TNS Advanced Serum, what’s in it, how to use it, and my honest review + results. Keep reading!

Like I mentioned above, I first learned about the SkinMedica TNS Advanced Serum from the esthetician who did my facial. I told her that my main concern was aging skin and wrinkles, and this serum was her #1 recommendation. It’s designed to visibly improve wrinkles, fine lines, skin tone and texture, AND it’s clinically proven to address sagging skin. I’ve been using it for about two months, and I’ve noticed that my skin has MUCH more elasticity and the deeper lines around my mouth have lessened significantly.

These fine lines have really started to bother me in the past year as they’ve become more pronounced. I get that aging happens, but these bother me especially for some reason. But, they have improved significantly since I started using the TNS Serum and aren’t as deep and noticeable when my face is at rest and when smiling.

You can see a significant difference in the lines in these photos.

TNS Advanced Serum before and after

This photo is before I started using the serum. You can see also see the lines around my mouth.

SkinMedica Serum honest review

Here is a photo from the day when I’m writing this. Impressive, right?

SkinMedica Serum results

The clinical trials also speak for themselves (source):
  • A third-party, validated psychometric scale revealed that patients felt they looked up to 6 years younger after 12 weeks.
  • Significant improvements in the appearance of sagging skin after 8 weeks.
  • Subjects felt increasingly more satisfied with continued use measured over 24 weeks.

I am absolutely satisfied… and that’s impressive considering it’s a $300 product!! Sometimes pricey products don’t live up to their price or the hype, but this one does. Because the serum is expensive, I try to make it last as long as possible. Currently, I only use it at night and only about 4 nights a week, versus every night. I purchased it in early January and as of the time of publishing (March 30), it hasn’t run out!  (The nights that I don’t use this serum, I alternate with this Overnight Resurfacing Peel.)

SkinMedica TNS Advanced+ Serum Key Ingredients

Let’s get into the key ingredients. There are two chambers in this serum that both dispense when you pump the serum into your hand. Together, they create a blend of marine extracts and peptides that support the collagen and elastin in your skin. It’s worth noting that the product is fragrance-free, so if you’re sensitive to scents like I am, this one shouldn’t be an issue.

Chamber #1


This formula acts on multiple levels to help give you the anti-age results you’re aiming for. TNS-MR is a highly active blend of two peptides: Progeline (Trifluoroacetyl Tripeptide-2) and Prolixir S20 (Dimer Tripeptide-43)

Progeline helps your skin repair itself by stopping progerin (which interrupts important tissue repair processes, leading to visible signs of skin aging). And Prolixir S20 is a dimer tripeptide designed to help sustain successful aging (less sagging and wrinkles).

In simpler terms, it’s a combination of next-generation growth factor blend that supports healthy skin functions and an innovative peptide complex that nourishes your skin.

Chamber #2

Renessensce (RSC) Advanced

The second chamber contains Renessensce (RSC) Advanced, which is a mixture of botanicals, marine extracts, such as chlorella, saccharide isomerate, hydrolyzed linseed extract, and grape stem cell extract (the grape extract contains antioxidants that help maintain adult skin cell production). These support results of the ingredients in chamber #1.

This blend of extracts and peptides includes other ingredients as well, which you can find here.

How to Use the SkinMedica TNS Advanced+ Serum

Step 1

Cleanse your face with your nightly cleanser. I love the Countertime cleansing oil.

Step 2

After cleansing, apply your toner or essence. I use the Countertime Essence (review here).

Step 3

Once your toner or essence has absorbed, dispense a single pump of the SkinMedica TNS Advanced+ Serum onto your fingertips or the back of your hand. Blend the product before applying to your face. Avoid getting in eyes, but apply all over the face and bring any leftover product to your neck and chest (key for making sure your decolletage stays youthful!)

Step 4

Follow with your night time moisturizer and eye cream. I love the Countertime Supreme Cream and the Ultra Renewal Eye Cream.

My Honest Review of the SkinMedica TNS Advanced+ Serum

Amazing results

I was really hopeful that I would see great results since the cost of the serum is high. But I’ve been shocked by just HOW good the results have been. I saw visible improvements in my smile lines and the line between my eyebrows after about a week or two of using it. My skin also feels much more taut (without feeling dry or tight!), which is proof that it’s preventing/restoring sagging skin. It really is like my younger skin’s elasticity is coming back!

When you’re doing your research, you may come across SkinMedica TNS Essential Serum and wonder what the difference is (I did!). To make things simple, the SkinMedica TNS Essential Serum is the original serum that SkinMedica made, and the TNS Advanced Serum is the updated version that gives results faster. Both are great skin care products, but for just a smidge extra, you get faster results of the TNS Advanced Serum. Maybe if you don’t have that many signs of aging or you’re a bit younger than I am, the cheaper option could be a good one to start with!

This side by side comparison shows the visible results pretty well. See how my skin has improved in 10 weeks of use?

serum to improve wrinkles

Fragrance free

I’m sensitive to most scents, so the fact that this serum is fragrance free is a major bonus for me.

Lasts a long time

While the serum is very expensive, I’m still on the first bottle 2+ months after buying it. Keep in mind that I don’t use it every night and I don’t typically use it in the AM, so the timeframe will be shorter if this is your daily serum, both AM and PM. Note that you don’t need to use a lot of product to get results. With all skincare products, you want just enough to cover skin. You don’t need a thick layer. A single pump dispenses a VERY small amount — about a black bean size — which is just enough to cover my face when blended in. And then, whatever is left on my hands, I put on my neck and chest and rub into my hands (another spot that shows age quickly!)

Not heavy or greasy

Some anti-aging products feel very heavy or make my skin feel tight.  That is NOT the case with this. It’s very lightweight and feels hydrating right away.

High price point

This is the only thing I dislike about the serum. It costs $295 for 1 oz, which feels extreme to me. However, I’ve been so impressed that I ordered another when I saw it go on sale.

Easy to find

One great thing about this serum is that you can find it easily online, and I’ve seen it on sale multiple times. I order wherever I can find the best deal. At times that’s at DermStore, and at other times, I’ve found it on LovelySkin or  SkinStore on sale.

If you have any questions about this serum, let me know. This post is NOT sponsored and I paid for the product with my own money. 🙂 And as always, I share my very honest feedback!

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  • Reply
    Frances Mattre

    Thank you for a comprehensive report on the TNS serum. I am currently using it and find it works much to my satisfaction. I have had a 5 microderm series and have another to go. I started the TNS after my 3rd microderm. I used it – 1 pump 2 times a day for 37 days. I ran out yesterday unexpectedly. Paying $295 for it comes to $8.00 day or $4.00 a pump. $56. a week. It is quite expensive, but I have gotten excellent results and will sacrifice something to continue using it. Amazon has it on sale for $250.75, so I ordered it there. I’m 76, my skin looks the best that it has ever been. Refreshed, pores minimized, fine wrinkles diminished. I alwasy had large pores and I spent tons of money on products to reduce, cover up and prime the surface with seemed to be wax. Now I am quite happy, only wear makeup for special occasions and look younger. Well that’s my testimonial….. thank you

    • Reply

      That’s so wonderful to hear!! Dermstore often has it on sale as well so I keep an eye out there too!

      • Reply
        Cassidy S

        Hi! I loved your post. How do you know that dermstore is a legit retailer and doesn’t have counterfeit products?

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